Transferrin

What is Transferrin?

Transferrin is the primary iron transport protein in blood, responsible for carrying iron from sites of absorption (intestine) and storage (liver, spleen) to tissues that need iron, particularly the bone marrow for red blood cell production. Transferrin levels reflect the body’s iron transport capacity and are closely related to Total Iron Binding Capacity (TIBC).

Why is it Tested?

Transferrin is measured to evaluate iron metabolism and diagnose iron-related disorders. It provides similar information to TIBC but as a direct protein measurement rather than a functional capacity test. Transferrin levels help distinguish iron deficiency from other causes of anemia and are useful for monitoring iron status, especially in chronic disease states.

Normal Ranges

What do Abnormal Results Mean?

Abnormal results are not a diagnosis. Always discuss your results with a qualified healthcare provider before making any medical decisions.

Low Transferrin

Decreased transferrin levels may indicate conditions affecting protein synthesis or increased losses:

• Liver disease reducing protein production
• Chronic inflammatory conditions
• Protein-energy malnutrition
• Nephrotic syndrome with protein loss
• Iron overload suppressing transferrin production

High Transferrin

Elevated transferrin typically indicates the body’s attempt to increase iron transport capacity and may suggest:

• Iron deficiency anemia
• Pregnancy (increased iron needs)
• Chronic blood loss
• Oral contraceptive use
• Estrogen therapy

How to Track Over Time

Monitoring transferrin trends helps assess iron status changes and evaluate treatment responses. During iron deficiency treatment, transferrin levels should gradually normalize as iron stores replenish. Since transferrin is also influenced by inflammation and liver function, tracking it alongside other iron markers provides a more complete picture of iron metabolism over time.